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The Lab For neurobiology of social behavior

John S.R, Tiwari R, Goussha Y, Amar R, Bizer A, Netser S, Wagner S. Simultaneous recording of ultrasonic vocalizations and sniffing from socially interacting individual rats using a miniature microphone. Cell Rep Methods. 3(11):100638, 2023. doi: 10.1016/j.crmeth.2023.10063.

Hochgerner H, Singh S, Tibi M, Lin Z, Skarbianskis N, Admati I, Ophir O, Reinhardt N, Netser S, Wagner S, Zeisel A. Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning. Nat Neurosci. 2023. doi: 10.1038/s41593-023-01469-3.

Mohapatra A.N & Wagner S. The role of prefrontal cortex in social interactions and animal models and the implications for autism spectrum disorder. Front. Psychiatry. 14:1205199, 2023. doi: 10.3389/fpsyt.2023.1205199.

Jada R, Borisov V, Laury E, Halpert S, Levy N.S, Wagner S, Netser S, Walikonis R, Carmi I, Berlin S and Levy A.P. Daily brief heat therapy reduces seizures in A350V IQSEC2 mice and is associated with correction of AMPA receptor-mediated synaptic dysfunction. Int. J. Mol. Sci. 24(4), 2023.

Jabarin R, Dagash W, Netser S, Singh S, Paul B.K, Barkai E and Wagner S. Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity. iScience, 26:2, 2023.

Jabarin R, Netser S and Wagner S. Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents. Molecular Autism. 13:41, 2022.

Netser S, Nahardiya G, Weiss-Dicker G, Dadush R, Goussha Y, John S.R, Taub M, Werber Y, Sapir N, Yovel Y, Harony-Nicolas H, Buxboum J.D, Cohen L, Crammer K and Wagner S. TrackUSF, a novel methodology for automated ultrasonic vocalization analysis, reveals modified calls in a rat model of autism. BMC Biology, 20:159, 2022.
doi: http://doi.org/10.1186/s12915-022-01299-y.

Haskal S, Netser S, Magalnik H, Briller M, Marzan D, Glatt S Abergel Y, and Wagner S. Social recognition laboratory mice requires integration of behaviorally-induced somatosensory, auditory and olfactory cues, Psychoneuroendocrinology, 143:105859, 2022.
doi: https://doi.org/10.1016/j.psyneuen.2022.105859.

John S.R, Dagash W, Mohapatra A.N, Netser S & Wagner S. Distinct dynamics of theta and gamma rhythmicity during social interaction suggest differential mode of action in the Medial Amygdala of Sprague Dawley rats and C57BL/6J mice, Neuroscience, 493, 69-80, 2022.

Mohapatra A.N, Netser S & Wagner S. Modular electrode array for multi-site extracellular recordings from brains of freely moving rodents, Current Protocols, 2, e399, 2022.

Goussha Y, Bar K, Netser S, Cohen L, Hel-Or Y & Wagner S. HybridMouse: A hybrid convolutional-recurrent neural network-based model for identification of mouse ultrasonic vocalizations, Front Behav Neuroscience, 15:810590, 2022.

Kopachev N, Netser S & Wagner S. Sex-dependent features of social behavior differ between distinct laboratory mouse strains and their mixed offspring, iScience, 25:2, 2022.

Jada R, Zag L, Borisov V, Levy N.S, Netser S, Jabarin R, Wagner S, Schragenheim-Rozales K, Shalgi R & Levy A.P. Housing of A350V IQSEC2 pups at 37°C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood, International Journal of Hyperthermia, 38:1, 1495-1501, 2021.

Lavenda-Grosberg D, Lalzar M, Leser N, Yaseen A, Malik A, Maroun M, Barki-Harrington L and Wagner S. Acute social isolation and regrouping cause short- and long-term molecular changes in the rat medial amygdala. Mol Psychiatry, 2021.

Wirth S, Soumier A, Eliava M, Derdikman D, Wagner S, Grinevich V and Sirigu A. Territorial blueprint in the hippocampal system. Trends Cogn Sci. 25(10):831-842, 2021.

Jabarin R, Levy N, Abergel Y, Berman J.H, Zag A, Netser S, Levy A.P and Wagner S. Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation. Transl Psychiatry. 11; 234, 2021.

Netser S, Meyer A, Magalnik H, Zylbertal A, Haskal S, Briller M, Bizer A, Grinevich V and Wagner S. Distinct dynamics of social motivation drive different patterns of social investigation behavior in C57BL/6J mice and Sprague Dawley rats. Nature Communications. 20; 11(1):5908, 2020.

Tang Y, Benusiglio D, Lefevre A, Hilfiger L, Althammer F, Bludau A, Hagiwara D, Baudon A, Darbon P, Schimmer J, Kirchner M.K, Roy R.K, Wang S, Eliava M, Wagner S, Oberhuber M, Conzelmann K.K, Schwarz M, Stern J.E, Leng G, Neumann I.D, Charlet A, Grinevich V. Social touch promotes inter-female communication via activation of oxytocin parvocellular neurons. Nature Neuroscience. 23(9): 1125-1137, 2020.

AnpilovS, Shemesh Y, Eren N, Harony-Nicolas H, Benjamin A, Dine J, Oliveira V, Forkosh O, Karamihalev S, Hüttl RE, Feldman N, Berger R, Dagan A, Chen G, Neumann I, Wagner S, Yizhar O and Chen A. Wireless optogenetic stimulation of oxytocin neurons in a semi-natural setup dynamically elevates both pro-social and agonistic behaviors. Neuron. 19;107(4):644-655.e7, 2020

Wagner S, Grinevich V, and Levkowitz G. Advances in neurohypophysial hormones research. Journal of Neuroendocrinology. 32(4):e12853, 2020.

Haskal S, Netser S, Hen Magalnik and Wagner S. Impaired sex preference, but not social and social novelty preferences, following systemic blockade of oxytocin receptors in adult male mice. Psychoneuroendocrinology. 116:104676, 2020.

Netser S, Haskal S, Magalnik H, Bizer A and Wagner S. A system for tracking the dynamics of social preference behavior in small rodents. J. Vis. Exp. (153), e60336, 2019.

Wagner S. Urocortins and their unfolding role in mammalian social behavior. Cell and Tissue Research. 375(1):133-142, 2019.

Frankiensztajn L. M., Gur-Pollack R, and Wagner S. A combinatorial modulation of synaptic plasticity in the rat medial amygdala by oxytocin, urocortin3 and estrogen. Psychoneuroendocrinology. 92:95-102, 2018.

Cohen L, Maroun M, and Wagner S. Behavior: Oxytocin promotes fearless motherhood. Current Biology. 28(8):R359-R361, 2018.

Rajamani K.T, Wagner S, Grinevich V, and Harony-Nicolas H. Oxytocin as a modulator of synaptic plasticity: Implications for neurodevelopmental disorders. Frontiers in synaptic neuroscience. 10:17, 2018.

Wagner S, and Harony-Nicolas H. Oxytocin and animal models for autism spectrum disorder. Curr Top Behav Neurosci. 35:213-237, 2017.

Netser S, Haskal S, Magalnik H, Wagner S. A novel system for tracking social preference dynamics in mice reveals sex- and strain-specific characteristics. Molecular Autism. 8:53, 2017.

Zylbertal A, Yarom Y, Wagner S. The slow dynamics of intracellular sodium concentration increase the time window of neuronal integration: A simulation study. Frontiers in Computational Neuroscience. 11:85, 2017.

Zylbertal A, Yarom Y, Wagner S. Synchronous infra-slow bursting in the mouse accessory olfactory bulb emerge from interplay between intrinsic neuronal dynamics and network connectivity. J Neuroscience. 37 (10): 2656-2672, 2017.

Harony-Nicolas H, Kay M, Hoffmann JD, Klein ME, Bozdaqi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. eLife. 6:e18904, 2017.

Maroun M. and Wagner S. Oxytocin and memory of emotional stimuli: Some dance to remember, some dance to forget. Biological Psychiatry. 1:79(3):203-12, 2016.

Garfinkel BP, Arad S, Neuner SM, Netser S, Wagner S, Kaczorowski CC, Rosen CJ, Gal M, Soreq H and Orly J. HP1BP3 expression determines maternal behavior and offspring survival. Genes Brain and Behavior. 17(7): 678-88, 2016.

Zylbertal A., Kahan A., Ben Shaul Y., Yarom Y., Wagner S. Prolonged intracellular Na+ dynamics govern electrical activity in accessory bulb mitral cells. PLOS Biology. 13(12): e1002319, 2015.

Leser N. and Wagner S. The effects of acute social isolation on long-term social recognition memory. Neurobiology of Learning and Memory. 124:97-103. 2015.

Tendler A. and Wagner S. Distinct types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory. eLife. 4:eo3614, 2015.

Shpak G., Zylbertal A. and Wagner S. Transient and sustained afterdepolarizations in accessory olfactory bulb mitral cells are mediated by distinct mechanisms that are differentially regulated by neuromodulators. Frontiers in Cellular Neuroscience. 8:432, 2015.

Gur, R., Tendler, A. and Wagner, S. Long-term social recognition memory is mediated by protein synthesis and oxytocin-dependent LTD in the medial amygdala. Biological Psychiatry. 76(5): 377-86, 2014.

Harony, H., Mamrut, S., Brodsky, L., Shahar-Gold, H., Barki-Harrington, L. and Wagner, S., Brain region-specific methylation in the promoter of the murine oxytocin receptor gene correlates with its expression. Psychoneuroendocrinology. 39:121-131, 2014.

Shahar-Gold, H., Gur, R. and Wagner, S. Rapid and reversible impairment of short- and long-term social recognition memory by acute isolation of adult rats. PLOS ONE. 31; 8(5):e65085, 2013.

Mamrut, S., Harony, H., Sood, R., Shahar-Gold, H. Gainer, H., Barki-Harrington, L. and Wagner, S. DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. PLOS ONE. 8(2): e56869, 2013.

Shpak, G., Zylbertal, A., Yarom, Y. and Wagner, S. Calcium Activated Sustained Responses Distinguish Accessory from Main Olfactory Bulb Mitral Cells, J. Neuroscience. 32(18):625-62, 2012.

Edry, E., Lamprecht, L., Wagner, S. and Rosenblum, K. Virally mediated gene manipulation in the adult CNS. Frontiers in Molecular Neuroscience. 26; 4:57, 2011.

Zibman, S., Shpak, G. and Wagner S. Distinct intrinsic membrane properties determine differential information processing between main and accessory olfactory bulb mitral cells. Neuroscience. 189:51-67, 2011.

Harony, H. and Wagner S. The Contribution of Oxytocin and Vasopressin to Mammalian Social Behavior: Potential Role in Autistic Spectrum Disorder. NeuroSignals. 18:82-97, 2010.

Wagner, S. and Yarom, Y. Excitation by GABA in the SCN reaches its time and place. European J. Neuroscience. 30: 1461, 2009.

Dulac, C. and Wagner, S. Genetic analysis brain circuits underlying pheromone signaling. Annual Review of Genetics. 40: 449-467, 2006.

Wagner, S., Gresser, A., Torello, A.T. and Dulac, C. A Multi-Receptor Genetic Approach Uncovers an Ordered Integration of VNO Sensory Inputs in the Accessory Olfactory Bulb. Neuron. 50: 697-709, 2006.

Wagner, S., Sagiv, N. and Yarom, Y., GABA-induced current and circadian regulation of chloride in neurones of the rat suprachiasmatic nucleus. The Journal of Physiology. 537 :853-869, 2001.

Wagner, S., Castel, M., Gainer, H. and Yarom, Y., GABA in the mammalian superchiasmatic nucleus and its role in diurnal rhythmicity. Nature. 387: 598-603, 1997.

Castel, M., Belenki, M., Cohen, S., Wagner, S. and Schwartz, W.J., Light-induced c-FOS expression in the mouse suprachiasmatic nucleus: Immuno-electron microscopy reveals co-localozation in multiple cell types. European J. Neuroscience. 9: 101-111, 1997.

Belenky, M., Wagner, S., Yarom, Y., Matzner, H., Cohen, S. and Castel, M., The suprachiasmatic nucleus in stationary organotypic culture. Neuroscience. 70: 127-143, 1996.