We have developed novel experimental setups and methodologies aimed to allow automated analysis of social behavior in rat and mouse models of ASD. Currently we are combining these setups and methodologies into one system enabling deep phenotyping of deficits in social behavior exhibited by these models. The system will analyze multiple parameters of social behavior, including physical interactions and vocal communication, as well as multiple physiological parameters such as sniffing, heart rate, body temperature and brain activity. Using these data, we obtain new insights into the mechanisms underlying the impaired social behavior displayed by animal models of ASD.